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WOMEN WHO USE DEPO-PROVERA INJECTABLE CONTRACEPTIVE FACE A HIGHER RISK OF DEVELOPING A MENINGIOMA BRAIN TUMOUR ACCORDING TO A NEW STUDY THAT COMES AS THE CONTRACEPTIVE'S MAKER, PFIZER, FACES LAWSUITS CLAIMING IT WAS AWARE OF THE POTENTIAL RISKS; ALLEGED NEWS. [1]
Depo-Provera
Depo-Provera is a prescription birth control injection containing a progestin hormone called medroxyprogesterone acetate; the FDS approved the drug for pregnancy prevention, in 1992; Alleged News. [2] According to Griffin, medroxyprogesterone acetate is a synthetic progesterone; [4] Depo Provera's link to meningioma brain tumours has given rise to Depo-Provera lawsuits against Pfizer, Pharmacia & Upjohn Company and authorized generic manufacturers, claiming the companies failed to warn the public of the risk; Alleged News. [2]
Meningioma and loss of bone density warnings
In September 2024, the European Medicines Agency issued a direct communication warning healthcare providers about Depo-Provera's link to meningiomas; Alleged News. [2] Canada's Depo label had also already included warnings that meningiomas have been reported with long-term use; Alleged News. [2]
In December 2025, the FDA added a meningioma (brain tumour) warning to Depo-Provera's label; Alleged News. [2] The label change followed a 2024 study published in the BMJ; Alleged News. [2] This research found that extended Depo-Provera use was associated with a significantly increased risk of meningioma; Alleged News. [2] Previously, the FDA had required a black box warning for loss of bone mineral density; Alleged News. [2]
Symptoms of meningioma can include;
Symptoms of meningioma can include;
- vision changes [2]
- hearing changes [2]
- weakness in the arms and legs [2]
- headaches that are worse in the morning [2]
- new-onset seizures [2]
- cognitive changes, including memory loss or confusion; Alleged News. [2]
Meningioma brain tumours
Studies have connected long-term use of Depo-Provera with meningioma brain tumours; Alleged News. [2] Meningioma brain tumour can grow in the tissues that cover the brain and spine; Alleged News. [2] Depo-Provera is a synthetic progesterone, and scientists have linked progesterone to the development of intracranial and cerebral meningiomas (brain tumours); Alleged News. [2]
Clinical Pharmacist Dazhi Liu told Drugwatch, "Meningioma is the most common type of primary brain tumour, accounting for approximately 30% of all brain tumours. These tumours originate in the meninges, which are the outer three layers of tissue between the skull and the brain that cover and protect the brain just under the skull," Alleged News. [2]
Roland et.al
A March 2024 French study published in BMJ found that Depo-Provera may be linked to a higher risk of developing a meningioma; Alleged News. [2] According to researchers, Depo-Provera users had a 5.6-fold increase in the risk of developing a meningioma after long-term use for more than a year; Alleged News. [2] Roland et al. Abstract conclusion stated that "Prolonged use of medrogestone, medroxyprogesterone acetate, and promegestone was found to increase the risk of intracranial meningioma." [3]
Griffin, Russell L
An American study published in Cancers in September 2024, confirmed the meningioma risk found in the BMJ study; Alleged News. [2] Researchers found that Depo-Provera use was associated with a 53% increase in odds of developing a meningioma, and the risk went up with duration of use; Alleged News. [2]
Griffin states in the conclusions section that "The current study reports an increased association between dMPA and meningioma, with the association being limited to cerebral meningioma." [4]
Depo-Provera side effects
Other Depo-Provera side effects allegedly include;
- intracranial meningioma [10]
- bleeding irregularities [5]
- bone mineral density changes and rate of bone loss[5]
- risk factor for development of osteoporosis [5]
- slight increase in breast cancer risk [2] and [5]
- invasive squamous cell cervical cancer [5]
- cancer risks [5]
- thromboembolic disorders; thrombotic disorders (thrombophlebitis, pulmonary embolism, cerebrovascular disorders, retinal thrombosis) [5]
- ocular disorders (eye disorders) [5]
- allergic reactions (swelling of face, neck or tongue) [2]
- allergic reactions [5]
- convulsions or seizures [2]
- ectopic pregnancy (pregnancy outside the uterus) [2], [5]
- depression [2]
- vision loss [2]
- injection site reactions [10]
- weight gain [10]
- delayed return of fertility [10]
- headaches or migraines [10]
- mood changes [10]
- breast tenderness [10]
- decreased libido; Alleged News [10]
- neonates from unexpected pregnancies may be at risk of low birth weight, which, in turn, is associated with increased risk of neonate death [5] [Neonate means newborn baby]
- several reports suggest an association between intrauterine exposure to progestational drugs in the first trimester of pregnancy and genital abnormalities in male and female fetuses [5] [Thus exposure to the injection during the first three months of pregnancy may lead to genital abnormalities in boys and girls
- detectable amount of Depo-Provera drug have been detected in the milk of mothers receiving Depo-Provera [5]; Alleged News
Depo-Provera adverse reactions
Menstrual irregularities (bleeding or amenorrhea, or both) [5]
Abdominal pain, or discomfort [5]
Weight changes [5]
Dizziness [5]
Headache [5]
Asthenia (weakness or fatigue) [5]
Nervousness [5]
Decreased libido or anorgasmia [5]
Breast pain [5]
Depression [5]
Rash [5]
Leukorrhea [5]
Arthralgia [5]
Pelvic pain [5]
Leg cramps [5]
Bloating [5]
Insomnia [5]
Hot flashes [5]
Vaginitis [5]
Backache [5]
No hair growth or alopecia [5]
Nausea [5]
Edema [5]
Acne [5]
Galactorrhea [5]
Melasma [5]
Chloasma [5]
Convulsions [5]
Changes in appetite [5]
Gastrointestinal disturbances [5]
Jaundice [5]
Genitourinary infections [5]
Vaginal cysts [5]
Dyspareunia [5]
Parasthesia [5]
Chest pain [5]
Pulmonary embolus [5]
Anemia [5]
Drowsiness [5]
Syncope [5]
Dyspnea [5]
Asthma [5]
Tachycardia [5]
Fever [5]
Excessive sweating and body odor [5]
Dry skin [5]
Chills [5]
Increased libido [5]
Excessive thirst [5]
Hoarseness [5]
Pain at injection site [5]
Blood dyscrasia [5]
Rectal bleeding [5]
Changes in breast size [5]
Breast lumps or nipple bleeding [5]
Axillary swelling [5]
Breast cancer [5]
Prevention of lactation [5]
Sensation of pregnancy [5]
Lack of return to fertility [5]
Paralysis [5]
Facial palsy [5]
Scleroderma [5]
Osteoporosis [5]
Uterine hyperplasia [5]
Cervical cancer [5]
Varicose veins [5]
Dysmenorrhea [5]
Hirsutism [5]
Unexpected pregnancy [5]
Thrombophlebitis [5]
Deep vein thrombosis [5]
Anaphylaxis [5]
Anaphylactoid reaction; Alleged News. [5]
Breast cancer risk
In the study "Depot medroxyprogesterone (Depo-Provera) and risk of breast cancer", Paul et al. concluded that "... these findings suggest that medroxyprogesterone may increase the risk of breast cancer in young women." [6]
Pfizer is facing over 1,200 federal lawsuits
Pfizer is facing over 1,200 federal lawsuits related to Depo-Provera, with women alleging that the pharmaceutical giant failed to warn them of the meningioma risk; Alleged News. [1] One Louisiana plaintiff, Ms Robin Phillip, said she developed an intracranial meningioma that caused her to lose vision in her left eye and struggle to walk; Alleged News. [1]
Women in South Africa
Four South African women who used Pfizer's Depo-Provera for decades blame the injectable contraceptive responsible for causing them to develop brain tumours; Alleged News. [7] Registered in South Africa as Depo-Provera, Provera, Petogen, Medroxyprogesterone Mylan, Sayana, Omrastoz, Trivina and Triclogyn, MPA is a synthetic oral and injectable form of progesterone, used for contraception and the management of endometriosis-associated pain; Alleged News. [7]
Cape Town South Africa
Ms Shene Gurling of Cape Town, had been taking the injection for 22 years, and was diagnosed with the tumour, which allegedly developed after prolonged use of Depo-Provera; Alleged News. [7] Ms Gurling had been on the injection since she was 17; at the end of 2023, Ms Gurling started having memory loss, and the vision in her left eye became impaired; Alleged News. [7] An MRI confirmed a brain tumour, which was affecting her optic nerve; Alleged News. [7] Ms Gurling underwent surgery, was dismissed by her employer for incapacity, and suffers from seizures, for which she is reliant on epilepsy medication; Alleged News. [7]
Gauteng South Africa
Ms Lynn van Rensburg of Gauteng, started using Depo-Provera 30 years before the time of the newspaper report; Alleged News. [7] At the end of 2023, Ms van Rensburg noticed increasing tearing of her eye, and she developed a stye, and sought medical advice; Alleged News. [7] Her eye was protruding, and a neurologist discovered a tumour behind her eye; Alleged News. [7]
Ms van Rensburg went into theatre for a nine-hour procedure, surgeons managed to remove 80% of the meningioma, which was entwined in her eye socket bone and skull, on the side of her brain; Alleged News. [7] Ms van Rensburg underwent severe depression and had to deal with the emotional trauma of her ordeal; Alleged News. [7]
In 2025, her eye started tearing and protruding again; Alleged News. [7] Ms van Rensburg said she never considered that her contraceptive could have been the cause of her tumour until she saw an article on a US website about the study, linking Depo-Provera to meningioma; Alleged News. [7] "I felt sick after reading it. I was on that injection for three decades. What made it worse for me is that so few women know about this. Across the country, people are getting the injection at government clinics, just like I used to. But do they know about the danger?" Alleged News. [7]
Vereeniging South Africa
Ms Belinda Potgieter of Vereeniging used Depo-Provera for 22 years, was left partially paralysed after the removal of her meningioma; and had to re-learn how to walk; Alleged News. [7] Her symptoms began with debilitating headaches, of which Ms Potgieter said, "I didn't expect seven tumours on my brain to be the cause," Alleged News. [7]
Ms Potgieter underwent surgery in 2024 to remove one tumour, which, if left untreated, would have left her paralysed; Alleged News. [7] Afterwards, she had to learn how to use her hands and walk again after the right side of her body was affected; Alleged News. [7] Ms Pogieter said, "If I had known the side effects ... I would never, never have taken it," Alleged News. [7]
Gqeberha South Africa
Ms Tanya Dippenaar of Gqeberha has nerve damage to her face, damaged brain cells, and the inability to experience taste on the left side of her mouth; Alleged News. [7] She had been living with a growth stretching from her frontal sinuses to the back of her ear, and into her temporal lobe for years, as it is too big for doctors to consider operating; Alleged News. [7] Ms Dippenaar had been on Depo-Provera from 2003 until 2014; Alleged News. [7] In 2017, she developed an ear infection, and for nearly five years, attended ENT doctors and specialists; Alleged News. [7] Ms Dippenaar also felt pressure in her left eye; Alleged News. [7]
In 2021, a CT scan revealed an extensive meningioma, Ms Dippenaar was told it cannot be removed as the risk of surgery outweighs any benefits, one risk being the possibility of facial paralysis; Alleged News. [7] She underwent 30 radiation sessions in efforts to reduce the tumour's size; the treatment caused memory loss, fatigue and severe head pain; Alleged News. [7]
Awareness
The women in South Africa were adamant they they wanted to spread awareness, so others do not have to go through what they have endured; Alleged News. [7]
Scotland
Women left with meningioma brain tumours after prolonged use of Depo-Provera have called on the Scottish government to better regulate the contraceptive injection; Alleged News. [8] Ms Tammy Croston, Ms Trish Saunders and Ms Donna McDonald were each left with meningioma brain tumours inside their skulls after taking the injection for several years; Alleged News. [8] Ms Tammy, from Cupar in Fife, was left without the use of one of her eyes after surgery to remove one of her four meningiomas went wrong; Alleged News. [8]
Ms Trish, from Aberdeen, was left with a half-paralysed face following surgery to remove the tumour from her head, while Ms Donna from Kilmarnock, now has a bulging eye due to a mass growing close to her eye socket; Alleged News. [8] All three women claim they were never told of the side-effect of the Pfizer-manufactured jab prior to usage; Alleged News. [8]
Depo-Provera tragic death
Ms Anita Peterson was only 47 years old when she died suddenly in October 2024; Alleged News. [9] An autopsy revealed that the cause of death was that Ms Peterson had been suffering from an intracranial meningioma - more commonly known as a brain tumour; Alleged News. [9] It was bleeding caused by this undiagnosed tumour that led to Ms Peterson's death; Alleged News. [9] What had caused the tumour itself was Depo-Provera, an injectable contraceptive containing medroxyprogesterone acetate (MPA); Alleged News. [9] Ms Peterson had used Depo-Provera from 2006 to 2012, and - although she had stopped taking the injection over a decade prior - it was too late; Alleged News. [9]
Depo-Provera lawsuits
Individuals are filing Depo-Provera lawsuits against multiple defendants, including Pfizer, Inc., Viatris, Inc., Greenstone, LLC, Prasco, LLC, and Pharmacia & Upjohn Co. LLC, because of intracranial meningiomas (brain tumours); Alleged News. [10] Many of these lawsuits have been consolidated in a multidistrict litigation called MDL-3140 IN RE; Depo-Provera (Depo Medroxyprogesterone Acetate) Products Liability Litigation; Alleged News. [10]
As of June 1, 2026, there are 5,508 Depo-Provera lawsuits pending
As of June 1, 2026, there are 5,508 Depo-Provera lawsuits pending in this federal litigation; Alleged News. [10] People are continuing to file Depo-Provera lawsuits; Alleged News. [10] It is important to file a case as soon as someone discovers that their brain tumour might have been caused by Depo-Provera use; Alleged News. [10] Cases will have to be filed before the statute of limitations expires; Alleged News. [10]
Individuals are filing lawsuits against the manufacturers of Depo-Provera, including Pfizer, Inc., alleging that the pharmaceutical company knew of the risk of brain tumours associated with the use of the drug, and failed to warn consumers; Alleged News. [10] Individuals who are diagnosed with a brain tumour after taking Depo-Provera may be entitled to damages, including compensation for any missed work, medical expenses, and pain and suffering; Alleged News. [10]
Ms Monique Jones v. Pfizer, et al.
In October 2024, Ms Jones filed a lawsuit in the Central District of California against the manufacturers of Depo-Provera, including Pfizer, Inc., for defective design, failure to warn, and negligence; Alleged News. [10] Ms Jones began receiving the injectable contraceptive in 2000 at the age of 20; she stopped taking Depo-Provera in 2024 after discovering a heavily calcified intracranial meningioma that could not be removed; Alleged News. [10]
Ms Lesley Noble and Justin Noble v. Pfizer et al.
A lawsuit filed in the Southern District of Indiana alleges Pfizer and other manufacturers violated the state's product liability act, engaged in negligent manufacturing, breached the express warranty, was negligent, and failed to warn consumers about the risks associated with the use of Depo-Provera; Alleged News. [10] The case centres around Lesley and Justin Noble, a married couple; Alleged News. [10] Ms Lesley developed a meningioma after taking Depo-Provera for several years, the brain tumour required radiation and surgery for removal; Alleged News. [10]
Ms Kristina Schmidt v. Pfizer et al.
Plaintiff Kristina Schmidt filed a lawsuit in the Northern District of California against Pfizer and other manufacturers of Depo-Provera, alleging that the companies knew or should have known about the risk of developing intracranial meningiomas associated with the use of the contraceptive and failed to warn consumers; Alleged News[10]. Ms Schmidt developed a brain tumour while taking the prescription injectable; she suffered debilitating headaches, dizziness, and vertigo; Alleged News. [10] Surgical intervention was required to remove the Sylvian fissure meningioma; Alleged News. [10]
Depo-Provera Lawsuit currently is an active lawsuit
Lawsuit Tracker gives information regarding the Depo-Provera Lawsuit, which currently is an active lawsuit; Alleged News. [10] The link to their website, is at number [10] below; Alleged News. [10]
Drugwatch
Drugwatch gives information regarding Depo-Provera Lawsuit: Brain Tumour Claims & Updates; Alleged News. [11] A free case review is available in their website, the link to their website is at number [11] below; Alleged News. [11]
Anapol Weiss
In October 2024, The Women's Health Litigation Team at Anapol Weiss filed a lawsuit against Pfizer on behalf of a woman who used Depo-Provera for a long period, and developed a brain tumour; Alleged News. [12]
On the heels of recent research linking Depo-Provera to brain and spinal tumours, Anapol Weiss took swift action by filing nine lawsuits (as of January 2025), against Pfizer, the manufacturer of Depo-Provera; Alleged News. [12]
As a trusted Depo-Provera lawsuit attorney, Anapol Weiss is preparing additional lawsuits on behalf of other women who developed meningiomas after using Depo-Provera for a prolonged period; Alleged News. [12]
Individuals considering a Depo-Provera lawsuit case are able to contact Anapol Weiss through the website link at [12]; Alleged News. [12] Anapol Weiss may be contacted through their website link at [12], to get a Depo-Provera case started with a free consultation; Alleged News. [12]
Latest Depo-Provera Lawsuit updates
The judge scheduled the first trial for December 2026, and a ruling on Pfizer's preemption argument is awaited; Alleged News. [13]
.
[1] NY Post. Swartz, Tracey. October 17, 2025. Popular birth control is linked to brain tumors in new study - as over 1,000 women sue Pfizer over health risks; Alleged News
[2] Llamas, Michelle BCPA. Last update: June 1, 2026. Depo Provera: Risks, FDA Warnings and Legal Concerns; Alleged News
https://www.drugwatch.com/depo-provera/
[3] BMJ. Roeland et al. Use of progestogens and the risk of intracranial meningioma: national case control study. 2024
doi: https://doi.org/10.1136/bmj-2023-078078
https://www.bmj.com/content/384/bmj-2023-078078.long
[4] Cancers. Griffin, Russell L. 2024. The Association between Medroxyprogesterone Acetate Exposure and Meningioma
doi:10.3390/cancers16193362
https://pubmed.ncbi.nlm.nih.gov/39409982/
[5] Physician information Depo-Provera Contraceptive injection, medroxyprogesterone acetate injectable suspension, USP
https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20246scs019_depo-provera_lbl.pdf
[6] Paul et.al. Depot medroxyprogesterone (Depo Provera) and risk of breast cancer. 1989
doi:10.1136/bmj.299.6702.759
[7] SA women allege Pfizer knew about contraceptive tumour risk; Alleged News
https://www.medicalbrief.co.za/sa-women-allege-pfizer-knew-about-contraceptive-tumour-risk/
[8] Suter, Ruth. Daily Record. Women left with brain tumours after contraceptive jabs demand tighter measures; Alleged News
https://www.dailyrecord.co.uk/news/scottish-news/women-left-brain-tumours-after-36964877
[9] Live Action. FDA finally admits to the dangers of popular birth control; Alleged News
https://www.liveaction.org/news/fda-finally-admits-dangers-popular-birth-control
[10] Robert King, Attorney. Lawsuit Tracker. Depo-Provera Lawsuit - June 2026 Update; Alleged News
https://lawsuittracker.org/dangerous-drugs/depo-provera-lawsuit/
[11] Whitney Ray Di Bona, Esquire. Depo-Provera Lawsuit: Brain Tumor Claims & Updates; Alleged News
https://www.drugwatch.com/depo-provera/lawsuit/
[12] Anapol Weiss/ Philadelphia Mass Tort Lawyers/ Depo Provera Lawsuit Attorneys/ Depo-Provera Lawsuit; Alleged News
https://www.anapolweiss.com/philadelphia-mass-tort-lawyers/depo-provera-lawsuit-attorneys/
[13] Depo-Provera Lawsuit; Brain Tumor claims and updates; Alleged News
https://www.drugwatch.com/depo-provera/lawsuit/
With thanks to nypost.com, drugwatch.com, bmj.com, accessdata.fda.gov, medicalbrief.co.za, dailyrecord.co.uk, liveaction.org, lawsuitttracker.org and anapolweiss.com
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